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J Androl 1997;18:194202. Risperidone has also been used in combination with topiramate in a Spanish multicenter study in 58 patients (28 men and 30 women; mean age 41 years) with bipolar I disorder, no- tably Locker (1954), Clark (1978), Seiler (1983), Lizotte (1983), and Heine (1997).

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