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Overestimation of In Vivo Hepatic Clearance: Occasionally, a predicted Clh based on Cli, in vitro is higher than the measured Clh. 30) to (12. 25 mg acts quickest and is shortest in its duration of action. Their principle of operation is shown in Figure 12. (See the sidebar, What If the Wheels Fall Off?) What If the Wheels Fall Off.

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